Angioedema Symptoms

Signs of Deep Skin Swelling and When It Is Dangerous

Angioedema is swelling in the deeper layers of the skin and tissues beneath it. Symptoms usually develop over minutes to hours and may last up to about three days. It often appears together with hives but can occur alone.

Common Angioedema Symptoms

  • Swelling of the lips, tongue, eyelids, cheeks, hands, feet or genitals
  • Skin that looks puffy, tight or slightly red
  • Tingling, warmth or tenderness (more than itching)
  • Stomach cramps, nausea or vomiting if the gut is involved

For the broader condition, see angioedema.

Signs of an Airway Emergency

Swelling of the tongue, throat or voice box can cause hoarseness, trouble swallowing, noisy breathing or a feeling that the throat is closing.

Allergic Vs Non-Allergic Symptoms

Allergic angioedema is usually itchy and appears with hives. Bradykinin-mediated forms, such as hereditary angioedema or ACE inhibitor angioedema, are not itchy and do not come with hives.

When to Call 911

Call 911 right away if hives or swelling occur with difficulty breathing or swallowing, a tight or closing throat, a swollen tongue, lips or face, wheezing, faintness, or a sudden feeling of impending doom. Use an epinephrine auto-injector first if one has been prescribed to you, then call for emergency help.

When to See a Doctor

See a doctor if your symptoms last more than a few days, keep coming back, cover large areas, or interfere with sleep or daily life. The Hives Treatment Center, founded by Dr. Tiffany Young, is a San Francisco practice that evaluates and treats angioedema symptoms in person and online.

Frequently Asked Questions About Angioedema Symptoms

How long does angioedema last?

Allergic angioedema often resolves in 1 to 3 days. HAE attacks may last longer.

Is angioedema itchy?

Often not as much as hives; it feels tight or tender.

Can angioedema occur without hives?

Yes. Learn about idiopathic angioedema.

Get Relief for Your Hives

Recurring swelling needs a diagnosis so the right treatment can be used. Visit our hives treatment page to see the latest treatment options for your outbreak.

See Hives Treatment Options

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. If you think you are having a medical emergency, call 911.